The site, at the southwest corner of Palm Avenue, previously hosted city hall until the city built a new home nearby.
Investors want a piece of more projects like it.
The Orlando Medical & Professional Complex will add three buildings.
JMC officials said the project would cost $110 million. It hopes to break ground later this year and complete it in mid-2025.
Construction of the building will begin in spring 2024, and the building is scheduled to open in fall 2026.