At 12 stories and 300,000 square feet, the building will be a major addition to the Orlando skyline, located next to Interstate 4 just north of the Princeton Street exit in the Health Village.
The project is expected to be completed in spring 2022.
Upshot Capital Advisors LLC is seeking master plan approvals for a 177,350-square-foot medical office with a six-story parking garage
About 4,500 Citrus County residents last year chose the facility for their medical care. More than 100 people from Citrus County also work at the accredited hospital.
Mayo opened the five-story, 190,000-square-foot medical building for patients needing cancer, neurology and neurosurgical care in August 2018.